Evaluation of chemical phototoxicity, focusing on phosphorylated histone H2AX
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چکیده
منابع مشابه
Evaluation of chemical phototoxicity, focusing on phosphorylated histone H2AX
Histone H2AX is a minor component of nuclear histone H2A. The phosphorylation of histone H2AX at Ser 139, termed γ-H2AX, was originally identified as an early event after the direct formation of DNA double-strand breaks (DSBs) by ionizing radiation. Now, the generation of γ-H2AX is also considered to occur in association with secondarily formed DSBs by cellular processing such as DNA replicatio...
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Introduction: Coronary angiography is a Diagnostic-Therapeutic method involving ionizing radiation. This method causes to DNA damage with form double stranded breaks which is followed by the phosphorylation of the histone, H2AX. H2AX is a key factor in the repair process of damaged DNA which will accumulate to damage sites. In human cells, H2AX constitutes about 10% of the H2A ...
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ژورنال
عنوان ژورنال: Journal of Radiation Research
سال: 2014
ISSN: 0449-3060,1349-9157
DOI: 10.1093/jrr/rru105